Bulgarian Institute for Standardization
Standards – always a step ahead
Phone: +359 2 8174 523, +359 2 8174 504
E-mail: info@bds-bg.org
1797 Sofia, 13 "Lachezar Stanchev" Str., "Izgrev" Complex
ID number: 175079183, VAT number: BG175079183
Main menu

ISO/TS 4988:2022

Nanotechnologies — Toxicity assessment and bioassimilation of manufactured nano-objects in suspension using the unicellular organism Tetrahymena sp.

May 25, 2022

General information

60.60     May 25, 2022

ISO

ISO/TC 229

Technical Specification

07.120  

English  

Buying

Published

Language in which you want to receive the document

Scope

This document provides a reliable and repeatable method for simultaneous assessment of both exposure and toxicity of manufactured nano-objects (MNOs) using Tetrahymena sp. The ingested, internalized material (MNOs) indicates aquatic exposure.
This document is intended to be used by all the centers working with nano(eco)toxicity of MNOs and capable of culturing of Tetrahymena sp. The method uses Tetrahymena sp. to assess exposure and effects of MNOs. In addition, the test can be used by centers (laboratories) interested in investigating the biological interaction of MNOs with living cells.
This method is applicable to nano-objects such as nanoparticles, nanofibres of certain size (in a µm size range), nanoplates, as well as their aggregates and agglomerates.

Life cycle

NOW

PUBLISHED
ISO/TS 4988:2022
60.60 Standard published
May 25, 2022